منابع مشابه
Spo13 regulates cohesin cleavage.
A key aspect of meiotic chromosome segregation is that cohesin, the protein complex that holds sister chromatids together, dissociates from chromosome arms during meiosis I and from centromeric regions during meiosis II. The budding yeast protein Spo13 plays a key role in preventing centromeric cohesin from being lost during meiosis I. We have determined the molecular basis for the metaphase ar...
متن کاملSpo13 protects meiotic cohesin at centromeres in meiosis I.
In the absence of Spo13, budding yeast cells complete a single meiotic division during which sister chromatids often separate. We investigated the function of Spo13 by following chromosomes tagged with green fluorescent protein. The occurrence of a single division in spo13Delta homozygous diploids depends on the spindle checkpoint. Eliminating the checkpoint accelerates meiosis I in spo13Delta ...
متن کاملCohesin regulates VSG monoallelic expression in trypanosomes
Antigenic variation allows Trypanosoma brucei to evade the host immune response by switching the expression of 1 out of approximately 15 telomeric variant surface glycoprotein (VSG) expression sites (ESs). VSG ES transcription is mediated by RNA polymerase I in a discrete nuclear site named the ES body (ESB). However, nothing is known about how the monoallelic VSG ES transcriptional state is ma...
متن کاملCohesin cleavage is insufficient for centriole disengagement in Drosophila
distinct from whole mature pollen [11] is consistent with our finding that miRNAs do not appear to act across the vegetative/sperm cell interface. Our data clearly reveal the presence of different and cell-autonomous differences in miRNA activity in the mature pollen grain of Arabidopsis. They further highlight the importance of promoter specificity when using amiRs to target mRNAs in rapidly d...
متن کاملSpo13 Facilitates Monopolin Recruitment to Kinetochores and Regulates Maintenance of Centromeric Cohesion during Yeast Meiosis
BACKGROUND Cells undergoing meiosis perform two consecutive divisions after a single round of DNA replication. During the first meiotic division, homologous chromosomes segregate to opposite poles. This is achieved by (1) the pairing of maternal and paternal chromosomes via recombination producing chiasmata, (2) coorientation of homologous chromosomes such that sister chromatids attach to the s...
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ژورنال
عنوان ژورنال: Genes & Development
سال: 2002
ISSN: 0890-9369
DOI: 10.1101/gad.989302